Autologous Protein Solution (nSTRIDE) as a Novel Therapeutic Option in Osteoarthritis: Implications for Clinical Practice
DOI:
https://doi.org/10.58931/cpct.2025.3s0253Abstract
Osteoarthritis (OA) is a disabling disease affecting hundreds of millions of people globally. It develops through a combination of mechanical stress and aging, leading to chondrocyte dysfunction and an imbalance between matrix degradation and synthesis. This imbalance is driven by upregulation of matrix metalloproteinases and pro-inflammatory cytokines. The joint degeneration causes inflammation, pain, limited mobility, and a negative impact on one’s quality of life. There are a variety of treatments for OA, including lifestyle changes, physiotherapy, intra-articular injections, and more invasively, arthroplasty. Common intra-articular injections include corticosteroids, hyaluronic acid (HA), and platelet-rich plasma (PRP).
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