https://canadianprimarycaretoday.com/issue/feedCanadian Primary Care Today2025-10-30T15:13:33+00:00Open Journal Systemshttps://canadianprimarycaretoday.com/article/view/3-s02-AboualiAutologous Protein Solution (nSTRIDE) as a Novel Therapeutic Option in Osteoarthritis: Implications for Clinical Practice2025-10-30T15:13:33+00:00Jihad Abouali<p class="p1">Osteoarthritis (OA) is a disabling disease affecting hundreds of millions of people globally. It develops through a combination of mechanical stress and aging, leading to chondrocyte dysfunction and an imbalance between matrix degradation and synthesis. This imbalance is driven by upregulation of matrix metalloproteinases and pro-inflammatory cytokines. The joint degeneration causes inflammation, pain, limited mobility, and a negative impact on one’s quality of life. There are a variety of treatments for OA, including lifestyle changes, physiotherapy, intra-articular injections, and more invasively, arthroplasty. Common intra-articular injections include corticosteroids, hyaluronic acid (HA), and platelet-rich plasma (PRP).</p>2025-10-30T00:00:00+00:00Copyright (c) 2025 Canadian Primary Care Today